To report SUSPECTED ADVERSE REACTIONS contact Lambda Therapeutics Limited (Toll Free Number: 1-855-642-2594 or by email: safety.nexuspharma@lambda-cro.com) or the FDA (Toll Free Number: 1-800-FDA-1088 or by the MedWatch website at www.fda.gov/safety/MedWatch/). CDER Specifications. Deaths from liver failure have been reported. Because PA is a peripheral vasodilator in concentrations higher than the usual therapeutic range, transient high plasma levels which may occur especially during intravenous administration may produce temporary but at times severe lowering of blood pressure (see OVERDOSAGE and PRECAUTIONS). Administration through the dermal layer of the skin to the systemic circulation by diffusion. Local and/or parenteral administration may be indicated in different cases of genital tract infection. White, in Comprehensive Toxicology, 2010. Proper Use. Therefore, caution should be exercised to avoid overly rapid administration of PA. When a drug must be administered rapidly or in a precise or very high dose. Injection of drug directly into the heart may start the. Administration by means of an electric current where ions of soluble salts migrate into the tissues of the body. Route of administration and dosage form are aspects of drug delivery. One poorly absorbable antibiotic is vancomycin, which is recommended by mouth as a treatment for severe Clostridium difficile colitis.[24]. Editable Pharmaceutical Documents in MS-Word Format. Anal route. It also is not known whether PA can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Action may be topical (local), enteral (system-wide effect, but delivered through the gastrointestinal tract), or parenteral (systemic action, but delivered by routes other than the GI tract). If any of these hematologic disorders are identified, Procainamide therapy should be discontinued. Data Standards Manual (monographs), Recalls, Market Withdrawals and Safety Alerts, Electronic Regulatory Submission and Review. [41] They also have essentially 100% bioavailability and can be used for drugs that are poorly absorbed or ineffective when they are given orally. Source. 5.30.5.4 Route of Administration. For treatment of arrhythmias associated with anesthesia or surgical operation, the suggested dose is 100 to 500 mg by intramuscular injection. Medically reviewed by Drugs.com. Site of desired action: the action may be localised and approachable or generalised and not approachable. Administration to the outside of the membrane enveloping the fetus. However, PA has weaker vagal blocking action than does quinidine, does not induce alpha-adrenergic blockade, and is less depressing to cardiac contractility. Skin: Angioneurotic edema, urticaria, pruritus, flushing, and maculopapular rash have also occurred.