The researchers even suggested that the risk of statin-related muscle side effects was minimal compared to the greater effect in preventing heart disease, and  that grapefruit juice should not be contraindicated in people who are taking statins. The related drugs verapamil, diltiazem and amlodipine are not affected by grapefruit 1. Diuretics, which are often referred to as water pills, and remove excess sodium and water from your organism, as fluid build-up is a threat to your blood pressure. After Diagnosis: 11 Treatments For High Blood Pressure (Hypertension). Medication prescribed to lower cholesterol levels, specifically statins. Scientists have discovered that the quantity of CYP3A4 in the body varies from person to person, so the effects of grapefruit juice will also vary from one person to another. As a member of the citrus family, grapefruit is a good source of vitamin C, with a single fruit supplying at least half your daily requirement. Blood Pressure Medications. The high level of bitter naringenin present also has cholesterol-lowering properties. Aldosterone antagonists, which prevent a hormone called norepinephrine from narrowing your arteries. How do you know which medications don't combine well with grapefruit, and why is this? In other words, the interaction was deemed beneficial due to the increased cholesterol-lowering effect of the higher statin levels and, presumably, the grapefruit antioxidants. Important notification about information and brand names used in this article! Some of the following drugs are known to interact negatively with grapefruit: Some of the most common blood pressure meds include: As far as the calcium channel blockers are concerned, these meds are prescribed to high blood pressure patients who need to have their artery muscles relaxed, as constriction of these vessels prevents blood from circulating normally. How Effective Are Angiotensin-Converting Enzyme (ACE) Inhibitors For Coronary Artery Disease? // Leaf Group Lifestyle. Red grapefruit juice has the most powerful effect, and can lower ‘bad’ LDL-cholesterol by as much as 15% compared with around 7% for juice from blond grapefruit. Grapefruit has more pith and membranes than most citrus fruit. However, the FDA has required that medical companies specify any potential interactions on their labels, especially for over the counter drugs. It is important to check the drug information sheet provided with any medication you are taking, and to follow any instruction provided for avoiding grapefruit and its juice. Drugs to prevent organ rejection after a transplant. The first two are channel blockers, while the other two work to counteract angiotensin effects. While the fruit causes some drugs to stay in the body for a longer period of time, it has an opposite effect on some other drugs. Are You At Risk Of A Heart Attack Or Stroke? Taking one particular statin, lovastatin, with a glass of grapefruit juice was found to produce the same blood levels of the drug as when taking 12 tablets with water! Of the statin medications that are commonly used to treat high cholesterol, atorvastatin, simvastatin and lovastatin levels are increased by grapefruit. According to Harvard Medical School doctors, the effects of just one glass of grapefruit juice on the availability of liver enzymes persist for many hours 2. This happens because grapefruit juice can also interfere with drug transporters, which are proteins that help our bodies absorb the drugs by moving them to the cells. Losartan and eplerenone are prescribed for patients that have too much angiotensin in their bodies, causing high blood pressure. These are typically prescribed to treat high blood pressure and angina. Calcium channel blockers are among the most frequently-prescribed hypertension drugs. Of the statin medications that are commonly used to treat high cholesterol, atorvastatin, simvastatin and lovastatin levels are increased by grapefruit. what is it with grapefruit juice and pills? When the researchers assessed the resulting benefits in a 60-year old man with a raised LDL-cholesterol, his predicted risk of heart disease was significantly reduced by the combination of a statin plus grapefruit juice. Grapefruit interacts with a variety of other types of medication 2. On the other hand, eplerenone levels will greatly increase when it interacts with grapefruit juice. What kind of drug is Felodipine and for what is it used? Certain neurological and psychiatric medications are also processed by the same liver enzymes as grapefruit. Drinking 500ml daily of juice from the Sweetie  (a cross between grapefruit and pummelo), for example, significantly lowered blood pressure in people with hypertension from an average of 142/89 mmHg down to 136/81 mmHg within five weeks.